Contact us:
Tel: +34 946 572 524
Mail: gap@cicbiogune.es
Ana M Aransay
Functional Genomics UnitCIC bioGUNE
Parque Tecnológico de Bizkaia, Ed. 801A
48160 Derio, Bizkaia, Spain
Email : amaransay[at]cicbiogune.es
Phone : +34 944 061 325 (ext 4421)
Ana M. Aransay received her B.Sc. degree in Biology (specialty: Fundamental Biology) from the University of the Basque Country (UPV/EHU) in 1992. During the Ph.D. (granted by the Basque Government) at the Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine at the Faculty of Medicine of the University of Crete (Greece), under the supervision of Prof. Yannis Tselentis, she learnt all the key Molecular Biology techniques (isoenzymes, DNA cloning, DNA sequencing, PCR, PCR-RFLP, etc.) and also fundamentals of diagnosis, species molecular typing, phylogeny and epidemiological studies.
After receiving her PhD in 1999, she obtained two consecutive post-doctoral research grants from the Basque Country Government to carry out a project on population genetics of vectors of parasitic diseases. The post-doctoral research work was performed from 1999 to 2004, first at Entomology Department of the Natural history Museum of London (U.K.), under the supervision of Dr. Paul D. Ready and later, at the National Centre of Microbiology of the Instituto de Salud Carlos III in Madrid (Spain), under the supervision of Dr. Ricardo Molina.
Since November 2004, she is the responsible of the Genome Analysis Platform at CIC bioGUNE (Derio, Spain) where the main objectives are to set up state-of-the-art high throughput technologies to offer services for characterization of genomes from different points of view.
PublicationsPeer-reviewed articles:
- Violeta Lorén, Arce Garcia-Jaraquemada, Juan Naves, Xavier Carmona, Míriam Mañosa, Ana M. Aransay, José Luis Lavin, Ivelisse Sánchez, Eduard Cabré, Josep Manyé, Eugeni Domènech (2018)
ANP32E, a protein involved in steroid-refractoriness in ulcerative colitis, identified by a systems biology approach
J Crohns Colitis. 2018 Oct 17. doi: 10.1093/ecco-jcc/jjy171. - Mirian Sánchez-Morán, Juan Andrés Hernández, Jon Andoni Duñabeitia, Adelina Estévez, Laura Bárcena, Aintzane González-Lahera, María Teresa Bajo, Luis J Fuentes, Ana M. Aransay*, Manuel Carreiras* (*: Both authors equal contribution) (2018)
Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: implications of comorbid samples
PLOS ONE. 13 - 10, 31/10/2018 - Lorea Valcarcel, Alice Macchia, Natalia Martin, Ana Rosa Cortazar, Ariane Schaub, Mikel Pujana, Sonia Fernandez, Isabel Lacasa, Aida Santos, Ana Loizaga, Miguel Unda, Ivana Hermanova, Ianire Astobiza, Mariona Graupera, Julia Starkova, James Sutherland, Rosa Barrio, Ana M. Aransay, Arkaitz Carracedo, Veronica Torrano (2018)
Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer
Cancer Res. 2018 Sep 19. pii: canres.1669.2018. doi: 10.1158/0008-5472.CAN-18-1669. - Cortazar, A.R., Torrano V., Martín-Martín, N., Caro-Maldonado, A., Camacho, L., Hermanova, Guruceaga, E., Lorenzo-Martín, L.F., Caloto, R., Gomis, R.R., Apaolaza, I., Quesada, V., Trka, J., Gomez-Muñoz, A., Vincent, S., Bustelo, X.R., Planes, F., Aransay, A.M.,*, Carracedo, A.* (*: Both authors equal contribution) (2018)
CANCERTOOL: a visualization and representation interface to exploit cancer datasets
Cancer Res. 2018 Sep 19. pii: canres.1669.2018. doi: 10.1158/0008-5472.CAN-18-1669. - David Fernández-Ramos, Pablo Fernández-Tussy, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de Juan, Nicolás Navasa, Lucía Barbier-Torres, Imanol Zubiete-Franco, Jorge Simón, Agustín F Fernández, Ander Arbelaiz, Ana M. Aransay, José Luis Lavín, Naiara Beraza, María J. Perugorria, Jesús Banales, Erica Villa, Mario F. Fraga, Juan Anguita, Matías Avila, Carmen Berasain, Paula Iruzubieta, Javier Crespo, Shelly Lu, Marta Varela-Rey, Jose Mato, Teresa C. Delgado and Maria Luz Martinez-Chantar (2018)
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
Cell Death and Disease, 9:958 - Pazos Obregón F, Soto P, Lavín JL, Cortazar AR, Barrio R, Aransay AM, Cantera R. (2018)
Cluster Locator, online analysis and visualization of gene clustering.
Bioinformatics, Volume 34, Issue 19, 1 October 2018, Pages 3377 - 3379. doi: 10.1093/bioinformatics/bty336. - Julen Tomás-Cortazar*; Laura Plaza-Vinuesa*; Blanca de las Rivas; Jose Luis Lavin; Diego Barriales; Leticia Abecia; Jose Miguel Mancheño; Ana Maria Aransay; Rosario Muñoz; Juan Anguita*; Hector Rodriguez* (2018)
Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp. Polymorphum.
Microbial Cell Factories, 17(1):33. doi: 10.1186/s12934-018-0880-4 - Carreras-González A, Navasa N, Martín-Ruiz I, Lavín JL, Azkargorta M, Atondo E, Barriales D, Macías-Cámara N, Pascual-Itoiz MA, Sampedro L, Tomás-Cortázar J, Peña-Cearra A, Pellón A, Prados-Rosales R, Abecia L, Elortza F, Aransay AM, Rodríguez H, Anguita J. (2018)
A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi.
Emerg Microbes Infect. 2018 Mar 7;7(1):19. doi: 10.1038/s41426-017-0018-5. - Caro-Maldonado A, Camacho L, Zabala-Letona A, Torrano V, Fernández-Ruiz S, Zamacola-Bascaran K, Arreal L, Valcárcel-Jiménez L, Martín-Martín N, Flores JM, Cortazar AR, Zúñiga-García P, Arruabarrena-Aristorena A, Guillaumond F, Cabrera D, Falcón-Perez JM, Aransay AM, Gomez-Muñoz A, Olivan M, Morote J, Carracedo A. (2017)
Low-dose statin treatment increases prostate cancer aggressiveness.
Oncotarget. 2017 Oct 31;9(2):1494-1504. doi: 10.18632/oncotarget.22217. - Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. (2017)
Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470 - Iruarrizaga-Lejarreta M, Varela-Rey M, Fernández-Ramos D, Martínez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buqué X, Cave DD, Peña A, Rodríguez-Cuesta J, Aransay AM, Elortza F, Falcón-Pérez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martínez-Chantar ML, Lu SC, Mato JM. (2017)
Role of Aramchol in steatohepatitis and fibrosis in mice.
Hepatol Commun. 2017 Nov; 1(9):911-927. doi: 10.1002/hep4.1107 - Martín-Martín N, Zabala-Letona A, Fernández-Ruiz S, Arreal L, Camacho L, Castillo-Martin M, Cortazar AR, Torrano V, Astobiza I, Zúñiga-García P, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcárcel-Jiménez L, Arruabarrena-Aristorena A, Piva M, Sánchez-Mosquera P, Aransay AM, Gomez-Muñoz A, Barrio R, Sutherland JD, Carracedo A.(2017)
PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
Cancer Res. 2018 Jan 15;78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908. - Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A. (2017)
Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.
Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3558. - Julen Tomás-Cortázar, Itziar Martín-Ruiz, Diego Barriales, Miguel Ángel Pascual-Itoiz, Virginia Gutiérrez de Juan, Alfredo Caro-Maldonado, Nekane Merino, Alberto Marina, Francisco J. Blanco, Juana María Flores, James D. Sutherland, Rosa Barrio, Adriana Rojas, María Luz Martínez-Chantar, Arkaitz Carracedo, Carolina Simó, Virginia García-Cañas, Leticia Abecia, José Luis Lavín, Ana M. Aransay, Héctor Rodríguez, Juan Anguita (2017)
The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoyetic transplant.
Scientific Reports 7: 10740 (DOI:10.1038/s41598-017-11354-2) - Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. (2017)
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964 - Belén Rivero-Gutiérrez, Reyes Gámez-Belmonte, María Dolores Suárez, José Luis Lavín, Ana María Aransay, Mónica Olivares, Olga Martínez-Augustin, Fermín Sánchez de Medina, Antonio Zarzuelo (2017)
A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota
Molecular Nutrition and Food Research 61(8), (2017), doi:10.1002/mnfr.201600622 - Lavín JL, Sánchez-Morán M, Bárcena L, Cortazar AR, Macías-Cámara N, González M, Aransay AM. (2017)
A fistful of tips for a fruitful high throughput sequencing experiment.
BioEssays Volume 39(5): 1700037. - Merino-Azpitarte M, Lozano E, Perugorria MJ, Esparza-Baquer A, Erice O, Santos-Laso A, O'Rourke CJ, Andersen JB, Jiménez-Agüero R, Lacasta A, D'Amato M, Briz O, Jalan-Sakrikar N, Huebert RC, Thelen KM, Gradilone SA, Aransay AM, Lavín JL, Fernández-Barrena MG, Matheu A, Marzioni M, Gores GJ, Bujanda L, Marin JJ, Banales JM (2017)
SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma
Journal of Hepatology, pii: S0168-8278(17): 30114-30119. doi: 10.1016/j.jhep.2017.02.017 - Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavín Trueba JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gómez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM. (2017)
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.
Gastroenterology 152(6):1449-1461.e7. doi:10.1053/j.gastro.2017.01.015 - Ana R. Cortazar, José A. Oguiza, Ana M. Aransay*, José L. Lavín* (*, both corresponding authors) (2017)
VerSeDa: vertebrate secretome database
Database (Oxford) (1): baw171 - Ramon M Rodriguez, Beatriz Suarez-Alvarez, José L Lavín, David Mosén-Ansorena, Aroa Baragaño Raneros, Leonardo Márquez-Kisinousky, Ana M. Aransay, Carlos Lopez-Larrea (2017)
Epigenetic networks regulate the transcriptional program in memory and terminally differentiated CD8+ T cells
Journal of Immunology 198(2):937-949 (2017) - Suarez-Alvarez, Beatriz; Rodriguez, Ramón; Schlangen, Karin; Baragaño Raneros, Aroa; Márquez-Kisinousky, Leonardo; Fernandez, Agustin; Diaz-Corte, Carmen, Aransay, Ana M.; López-Larrea, Carlos (2017)
Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole genome DNA methylation pattern
Aging Cell 16(2):293-303 [DOI: 10.1111/acel.12552] - Natalia Martín-Martín, Marco Piva, Jelena Urosevic, Paula Aldaz, James D. Sutherland, Sonia Fernández-Ruiz, Leire Arreal, Verónica Torrano, Ana R. Cortazar, Evarist Planet, Marc Guiu, Nina Radosevic-Robin, Stephane Garcia, Iratxe Macías, Fernando Salvador, Giacomo Domenici, Oscar M. Rueda, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Patricia Zuñiga-García, Alfredo Caro-Maldonado, Lorea Valcárcel-Jiménez, Pilar Sánchez-Mosquera, Marta Varela-Rey, Maria Luz Martínez-Chantar, Juan Anguita, Yasir Ibrahim, Maurizio Scaltriti, Charles H. Lawrie, Ana M. Aransay, Juan L. Iovanna, Jose Baselga, Carlos Caldas, Rosa Barrio, Violeta Serra, Maria dM Vivanco, Ander Matheu, Roger R. Gomis, Arkaitz Carracedo (2016)
Stratification and therapeutic potential of PML in metastatic breast cancer
Nat Com 7: article 12595 - Verónica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zuñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena1, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, JasonW. Locasale, Roger R. Gomis and Arkaitz Carracedo (2016)
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
Nature Cell Biol 18(6):645-56 (DOI: 10.1038/ncb3357) - Felix Royo, Patricia Zuñíga-Garcia, Verónica Torrano, Ana Loizaga, Pilar Sanchez-Mosquera, Aitziber Ugalde-Olano, Esperanza González, Ana R. Cortazar, Laura Palomo, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Maria Berdasco, James D. Sutherland, Rosa Barrio, Amaia Zabala-Letona, Natalia Martín-Martín, Amaia Arruabarrena-Aristorena, Lorea Valcarcel-Jimenez, Alfredo Caro-Maldonado, Jorge Gonzalez-Tampan, Guido Cachi-Fuentes, Manel Esteller, Ana M. Aransay, Miguel Unda, Juan M. Falcón-Pérez, Arkaitz Carracedo (2016)
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Oncotarget 7(6):6835-6846 (DOI: 10.18632/oncotarget.6899) - Ana R. Cortazar, José A. Oguiza, Ana M. Aransay*, José L. Lavín* (*, both corresponding authors). (2015)
PECAS: Prokaryotic and Eukaryotic Classical Analysis of Secretome
Amino Acids. 2015 Dec;47(12):2659-63. doi: 10.1007/s00726-015-2058-2 - Lucy Carty, Jose A. Gomez-Sanchez, Marta Iruarrizaga-Lejarreta, Marta Palomo-Irigoyen, Marta Varela-Rey, Megan Griffith, Janina Hantke, Nuria Macias, Mikel Azkargorta, Igor Aurrekoetxea, Virginia Gutiérrez-De Juan, Harold B. J. Jefferies, Patricia Aspichueta, Félix Elortza, Ana M. Aransay, María L. Martínez-Chantar, Frank Baas, José M. Mato, Rhona Mirsky, Ashwin Woodhoo, Kristján R. Jessen. (2015)
Schwann cell autophagy, myelinophagy, clears myelin from injured nerves
Journal of Cell Biology 210(1):153-168 - Ugalde-Olano A, Egia A, Fernández-Ruiz S, Loizaga-Iriarte A, Zuñiga-García P, Garcia S, Royo F, Lacasa-Viscasillas I, Castro E, Cortazar AR, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Torrano-Moya V, Valcárcel-Jiménez L, Sánchez-Mosquera P, Caro-Maldonado A, González-Tampan J, Cachi-Fuentes G, Bilbao E, Montero R, Fernández S, Arrieta E, Zorroza K, Castillo-Martín M, Serra V, Salazar E, Macías-Cámara N, Tabernero J, Baselga J, Cordón-Cardo C, Aransay AM, Villar AD, Iovanna JL, Falcón-Pérez JM, Unda M, Bilbao R, Carracedo A. (2015)
The study of prostate cancer as a disease driven by altered PTEN function: How to overcome the methodological challenges
Methods 77-78:25-30 - María Salazar, Mar Lorente, Elena García-Taboada, Eduardo Pérez Gómez, David Dávila, Patricia Zúñiga-García, Juana María Flores, Antonio Rodríguez, Zoltan Hegedus, David Mosén-Ansorena, Ana M. Aransay, Sonia Hernández-Tiedra, Israel López-Valero, Miguel Quintanilla, Cristina Sánchez, Juan L. Iovanna, Nelson Dusetti, Manuel Guzmán, Sheila E. Francis, Arkaitz Carracedo, Endre Kiss-Toth and Guillermo Velasco. (2015)
TRIB3 suppresses tumorigenesis by controling mTORC2/AKT/FOXO signaling
Molecular & Cellular Oncology 2(3): e980134 - Rodriguez RM, Suarez-Alvarez B, Mosen-Ansorena D, Garcia-Peydro, M, Fuentes P, Garcia-Leon MJ, Gonzalez-Lahera A, Macias-Camara N, Toribio ML, Aransay AM, Lopez-Larrea C. (2015)
Regulation of the transcriptional program by DNA methylation during human αβ T-cell development
Nucleic Acids Research 43(2):760-774 - Salazar M, Lorente M, García-Taboada E, Pérez Gómez E, Dávila D, Zúñiga-García P, María Flores J, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S,
López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G. (2015)
Loss of Tribbles Pseudokinase-3 promotes AKT-driven tumorigenesis via selective FOXO inactivation
Cell Death and Differentiation 22(1):131-44 - Merino M., Alvarez-Fraga L., Gómez M.J., Aransay A.M., Lavín J.L., Chaves F., Bou G., Poza M. (2014)
Complete genome sequence of the multiresistant Acinetobacter baumannii AbH12O-A2, isolated during a large outbreak in Spain.
Genome Announcements 2(6): e01182-14 - Rafael Cantera, Maria J, Ferreiro, Ana M. Aransay and Rosa Barrio (2014)
Global gene expression shift during the transition from early neural development to late neuronal differentiation in Drosophila melanogaster.
PLOs ONE 9(5): e97703 - Arantza Infante, Andrea Gago, Garbiñe Ruiz de Eguino, Teresa Calvo-Fernández, Vanessa Gómez-Vallejo, Jordi Llop, Karin Schlangen, Ane Fullaondo, Ana M. Aransay, Abraham Martín, and Clara I. Rodríguez (2014)
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cells.
AGING-US (Albany NY) 6(4):264-80 (2014) - David Mosén-Ansorena, Naiara Tellería, Silvia Veganzones, Virginia de la Orden, María Luisa Maestro and Ana M. Aransay(2014)
seqCNA: an R package for DNA copy number analysis in cancer using high-throughput sequencing.
BMC genomics 15 (1), 178 - Marta Varela-Rey, Marta Iruarrizaga-Lejarreta, Juan José Lozano, Ana María Aransay, Agustín F. Fernandez, José Luis Lavin, David Mósen-Ansorena, María Berdasco, Marc Turmaine, Zigmund Luka, Conrad Wagner, Shelly C. Lu, Manel Esteller, Rhona Mirsky, Kristján R. Jessen, Mario F. Fraga, María L. Martínez-Chantar, José M. Mato, Ashwin Woodhoo (2014)
S-adenosylmethionine levels regulate the Schwann cell DNA methylome.
Neuron 81 (5), 1024-1039) - Cortazar AR, Aransay AM, Alfaro M, Oguiza JA, Lavín JL (2014)
SECRETOOL: integrated secretome analysis tool for fungi.
Amino Acids. 46(2):471-3 - Amparo Perez, Ana Loizaga, Raquel Arceo, Isabel Lacasa, Ainara Rabade, Kerman Zorroza, David Mosen-Ansorena, Esperanza Gonzalez, Ana M. Aransay, Juan M. Falcon-Perez, Miguel Unda-Urzaiz and Felix Royo (2014)
A Pilot Study on the Potential of RNA-Associated to Urinary Vesicles as a Suitable Non-Invasive Source for Diagnostic Purposes in Bladder Cancer
Cancers 2014, 6(1), 179-192; doi:10.3390/cancers6010179 - Soraya Rumbo-Feal, Manuel J Gomez, Carmen Gayoso, Laura álvarez-Fraga, María P Cabral, Ana M Aransay, Naiara Rodríguez-Ezpeleta, Ane Fullaondo, Jaione Valle, Germán Bou, Margarita Poza, PhD (2013)
Whole transcriptome analysis of Acinetobacter baumannii assessed by RNA-sequencing reveals different mRNA expression profiles in biofilm compared to planktonic cells
PLOS ONE 8(8): e72968 - Felix Royo, Karin Schlangen, Laura Palomo, Esperanza Gonzalez, Javier Conde- Vancells, Agustin Berisa, Ana M. Aransay and Juan M. Falcon-Perez
Transcriptome of extracellular vesicles released by hepatocytes
PLOS ONE 8(7): e68693 (2013) - Anna Delprato, Ana M Aransay, SYSGENET consortium, Heike Kollmus, Klaus Schughart and Juan M Falcon-Perez (2013)
Meeting report of the European mouse complex genetics network SYSGENET
Mammalian Genome24(5-6):190-197 - Klaus Schughart, Claude Libert, SYSGENET consortium and Martien J. Kas (2013)
Controlling complexity: The clinical relevance of mouse complex genetics
European Journal of Human Genetics (Advance OnLine May 2013) CLAVE: A - Roberto Díaz-Peña, Patricia Castro-Santos, Ana M. Aransay, Jacome Brüges-Armas, Fernando M. Pimentel-Santos, Carlos López-Larrea (2013)
Genetic study confirms association of HLA-DPA1*01:03 subtype with Ankylosing Spondylitis in HLA-B27-positive populations
Human Immunology; 74(6):764-767 - Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Le Marchand-Brustel Y, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM.(2013).
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.
Hepatology. 2013 Feb; 57(2):505-14. doi: 10.1002/hep.26052. Epub 2012 Nov 27.
PMID: 22961556 [PubMed - in process]
Related citations. - Mosén-Ansorena D, Aransay AM. (2013)
Bivariate segmentation of SNP-array data for allele-specific copy number analysis in tumour samples.
BMC Bioinformatics, 14:84. - Ferreiro MJ, Rodríguez-Ezpeleta N, Pérez C, Hackenberg M, Aransay AM, Barrio R, Cantera R.(2012).
Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.
BMC Genomics. 2012 Sep 15; 13:483. doi: 10.1186/1471-2164-13-483.
PMID: 22978642 [PubMed - in process]
Free PMC Article.
Related citations. - Mosé-Ansorena D, Aransay AM, Rodríguez-Ezpeleta N.(2012).
Comparison of methods to detect copy number alterations in cancer using simulated and real genotyping data.
BMC Bioinformatics. 2012 Aug 7; 13:192. doi: 10.1186/1471-2105-13-192.
PMID: 22870940 [PubMed - in process]
Free PMC Article.
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Crosstalk between Ras and LKB1 in glycine N-methyltransferase-deficient hepatocellular carcinoma
FEBS JOURNAL 279 (Special Issue: SI, Supplement: 1): 158-158, SEP 2012 - Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. (2012)
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1.
Gastroenterology 143, (3):787-798 (IF2012: 12.821) - Ruiz de Eguino G, Infante A, Schlangen K, Aransay AM, Fullaondo A, Soriano M, García-Verdugo JM, Martín AG, Rodríguez CI.(2012).
Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles.
Stem Cells Transl Med. 2012 Apr; 1(4):309-21. doi: 10.5966/sctm.2011-0010. Epub 2012 Apr 2.
PMID: 23197810 [PubMed - indexed for MEDLINE]
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Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Gastroenterology. 2012 Sep; 143(3):787-98.e1-13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8.
PMID: 22687285 [PubMed - indexed for MEDLINE]
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microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population.
Clin Microbiol Infect. 2012 Aug; 18(8):E273-82. doi: 10.1111/j.1469-0691.2012.03849.x. Epub 2012 Apr 24.
PMID: 22524533 [PubMed - indexed for MEDLINE]
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The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.
J Neurosci. 2012 Apr 4; 32(14):4944-58. doi: 10.1523/JNEUROSCI.5868-11.2012.
PMID: 22492050 [PubMed - indexed for MEDLINE]
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A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis.
Ann Rheum Dis. 2012 May; 71(5):714-7. doi: 10.1136/annrheumdis-2011-200661. Epub 2012 Jan 31.
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A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
Genes and Immunity 13:21-28 (2012); doi:10.1038/gene.2011.44 - Díaz-Peña R, Aransay AM, Bruges-Armas J, López-Vázquez A, Rodríguez-Ezpeleta N, Mendibil I, Sánchez A, Torre-Alonso JC, Bettencourt BF, Mulero J, Collantes E, López-Larrea C. (2011).
Fine mapping of a major histocompatibility complex in ankylosing spondylitis: association of the HLA-DPA1 and HLA-DPB1 regions.
Arthritis Rheum. 2011 Nov; 363(11):3305-12. doi: 10.1002/art.30555.
PMID: 21769851 [PubMed - indexed for MEDLINE]
Free PMC Article.
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miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments.
Nucleic Acids Res. 2011 Jul; 39(Web Server issue):W132-8. doi: 10.1093/nar/gkr247. Epub 2011 Apr 22.
PMID: 21515631 [PubMed - indexed for MEDLINE]
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Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation.
Stem Cells. 2011 Jan; 29(1):141-53. doi: 10.1002/stem.562.
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High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populations.
Hum Genet. 128(1):113-117 - Santin I, Castellanos-Rubio A, Aransay AM, Gutierrez G, Gaztambide S, Rica I, Vicario JL, Noble JA, Castaño L, Bilbao JR (2009).
Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.
Genes Immun. 10(6):596-600 - Hackenberg M, Sturm M, Langenberger D, Falcón-Pérez JM, Aransay AM (2009)
miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments.
Nucleic Acids Res. 37: W77-W83 - Collao X, Palacios G, Sanbonmatsu-Gámez S, Pérez-Ruiz M, Negredo AI, Navarro-Marí JM, Grandadam M, Aransay AM, Lipkin WI, Tenorio A, Sánchez-Seco MP (2009).
Genetic diversity of toscana virus.
Emerg Infect Dis. 15:574-7. - Otaegui D, Zuriarrain O, Castillo-Triviño T, Aransay A, Ruíz-Martinez J, Olaskoaga J, Marti-Masso J, Lopez de Munain A (2009).
Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients.
Mult Scler. 15:124-8. - Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM (2008).
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Hepatology. 47:1191-9. - Castellanos-Rubio A, Martin-Pagola A, Santín I, Hualde I, Aransay AM, Castaño L, Vitoria JC, Bilbao JR (2008).
Combined functional and positional gene information for the identification of susceptibility variants in celiac disease.
Gastroenterology. 134:738-46. - Santin I, Castellanos-Rubio A, Aransay AM, Castaño L, Vitoria JC, Bilbao JR (2008).
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Tissue Antigens. 71:247-9. - O'Doherty C, Roos IM, Antiguedad A, Aransay AM, Hillert J, Vandenbroeck K (2007).
ITGA4 polymorphisms and susceptibility to multiple sclerosis.
J Neuroimmunol. 189:151-7. - Bilbao JR, Calvo B, Aransay AM, Martin-Pagola A, Perez de Nanclares G, Aly TA, Rica I, Vitoria JC, Gaztambide S, Noble J, Fain PR, Awdeh ZL, Alper CA, Castaño L (2006).
Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease.
Genes Immun. 7:550-4. - Melero-Alcíbar R, Molina R, Aransay AM (2006).
Aportación al conocimiento de la fauna de culícidos (Diptera: Culicidae) de las Islas Baleares: isla de Ibiza.
Boletín Sociedad Entomológica Aragonesa. 38:331-332 - Parvizi P, Mauricio I, Aransay AM, Miles MA, Ready PD (2005).
First detection of Leishmania major in peridomestic Phlebotomus papatasi from Isfahan province, Iran: comparison of nested PCR of nuclear ITS ribosomal DNA and semi-nested PCR of minicircle kinetoplast DNA.
Acta Trop. 93:75-83.. - Aransay AM, Testa JM, Morillas-Marquez F, Lucientes J, Ready PD (2004).
Distribution of sandfly species in relation to canine leishmaniasis from the Ebro Valley to Valencia, northeastern Spain.
Parasitol Res. 94:416-20. - Aransay AM, Ready PD, Morillas-Marquez F (2003).
Population differentiation of Phlebotomus perniciosus in Spain following postglacial dispersal.
Heredity. 90:316-25. - Aransay AM, Malarky G, Ready, P.D (2001).
Isolation (with enrichment) and characterization of trinucleotide microsatellites from Phlebotomus perniciosus, a vector of Leishmania infantum.
Molecular Ecology Notes. 1:176-178. - Spyridaki I, Psaroulaki A, Aransay AM, Scoulica E, Tselentis Y (2000).
Diagnosis of quinolone resistant Coxiella burnetii strains by PCR-RFLP.
Journal of Clinical Laboratory Analysis. 14:59-63. - Aransay AM, Scoulica E, Tselentis Y (2000).
Detection and identification of Leishmania DNA within naturally infected sand flies by seminested PCR on minicircle kinetoplastic DNA.
Appl Environ Microbiol. 66:1933-8. - Aransay AM, Scoulica E, Tselentis Y, Ready PD (2000).
Phylogenetic relationships of phlebotomine sandflies inferred from small subunit nuclear ribosomal DNA.
Insect Mol Biol. 9:157-68. - Aransay AM, Scoulica E, Chaniotis B, Tselentis Y (1999).
Typing of sandflies from Greece and Cyprus by DNA polymorphism of 18S rRNA gene.
Insect Mol Biol. 8:179-84. - E. Scoulica, A. Aransay, Y. Tselentis (1995).
Molecular characterization of the OXA-7 beta-lactamase gene..
Antimicrobial agents and chemotherapy. 39 (6), 1379-1382.
See Ana M. Aransay's PubMed publication records here
Book edition:- Lavín-Trueba, J.L. and Aransay, A.M. (2016)
Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing.
Springer, New York, NY, USA, (ISBN 978-3-319-31348-1) (DOI: 10.1007/978-3-319-31350-4). - Rodriguez-Ezpeleta N., Hackenberg M. and Aransay A.M. (2012).
Bioinformatics for High Throughput Sequencing
- Teresa Cardoso Delgado, Mikel Azkargorta, Jose Luis Lavín-Trueba, Marta Varela-Rey, Monika Gonzalez, José M. Mato, Felix Elortza, Ana M. Aransay, María-Luz Martínez-Chantar (2018)
Biomarkers in NAFLD
Chapter 5 at "FATTY LIVER DISEASE: a reality with many questions". Eds. Jose Luis Olcoz Goñi & Francisco
Jorquera Plaza. EOLAS ediciones - Lavín-Trueba, J.L. and Aransay, A.M. (2016)
The High Throughput Sequencing technologies triple-W discussion: Why to use HTS, What is the optimal HTS method to use, Which data analysis workflow to follow
Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing. - Israel Cruz, Ana M. Aransay, Isabel Cuesta (All authors, equal contribution). (2015)
La (R)Evolución del Diagnóstico Molecular en las Enfermedades Tropicales.
Diagnóstico de las Enfermedades Desatendidas: moléculas y trópico (Pigmalion, Eds.: E. Rodriguez-de las Parras, J.M. Rubio-Muñoz & J. Alvar-Ezquerra), Chapter 1, pp:15-29. - Ana M. Aransay, Laura Barcena, Aintzane Gonzalez-Lahera, Nuria Macias-Camara. (2015)
Chapter 5: Single cell genome and transcriptome processing prior to high-throughput sequencing
Mammary Stem Cells: Methods in Molecular Biology 1293 (Humana Press, Ed: Maria dM Vivanco), Chapter 5, pp:83-114 - Rodriguez-Ezpeleta N., Aransay A.M..(2012).
Introduction
Bioinformatics for High Throughput Sequencing , pp. 1-9 - Aransay A.M., Matthiesen R. and Regueiro M.M.(2010).
SNP-PHAGE. High throughput SNP discovery pipeline
Bioinformatics in clinical omics research, In Methods Mol Biol.(Humana Press Inc.) 593:49-65
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