Contact us:
Tel: +34 946 572 524
Mail: gap@cicbiogune.es
Ana Rosa Cortazar
Functional Genomics UnitCIC bioGUNE
Parque Tecnológico de Bizkaia, Ed. 801A
48160 Derio, Bizkaia, Spain
Email : acortazar[at]cicbiogune.es
Phone : +34 946 572 524 (ext. 4420)
Ana Rosa Cortazar received her BSc degree in Computer Science from de University od Deusto in 2009. During the last two years of her studies she worked as assistant teacher on the Development Department, where she discovered Bioinformatics. After that, she obtained her MSc. in Bioinformatics and Biostatistics at the Universidad Oberta de Catalunya in 2011.
She first joined CIC bioGUNE as part of the IT Service in 2011, where she worked mainly as software developer. Due to this, she got in contact with the Genome Analysis Platform and began working as a assistant technician in Bioinformatics. Finally, she joined the Genome Analysis Group in 2013.
Recent publications
- Royo F, Azkargorta M, Lavin JL, Clos-Garcia M, Cortazar AR, Gonzalez-Lopez M, Barcena L, Del Portillo HA, Yáñez-Mó M, Marcilla A, Borras FE, Peinado H, Guerrero I, Váles-Gómez M, Cereijo U, Sardon T, Aransay AM, Elortza F, Falcon-Perez JM.
Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules.
Front Cell Dev Biol. 2021 Jan 12;8:613583. doi:10.3389/fcell.2020.613583. PMID: 33511119; PMCID: PMC7835421. - Barriales D, Martín-Ruiz I, Carreras-González A, Montesinos-Robledo M,Azkargorta M, Iloro I, Escobés I, Martín-Mateos T, Atondo E, Palacios A,Gonzalez-Lopez M, Bárcena L, Cortázar AR, Cabrera D, Peña-Cearra A, van LiempdSM, Falcón-Pérez JM, Pascual-Itoiz MA, Flores JM, Abecia L, Pellon A, Martínez-Chantar ML, Aransay AM, Pascual A, Elortza F, Berra E, Lavín JL, Rodríguez H,Anguita J.
Borrelia burgdorferi infection induces long-term memory-likeresponses in macrophages with tissue-wide consequences in the heart.
PLoS Biol.2021 Jan 4;19(1):e3001062. doi: 10.1371/journal.pbio.3001062. PMID: 33395408;PMCID: PMC7808612. - Shahrouzi P, Astobiza I, Cortazar AR, Torrano V, Macchia A, Flores JM,Niespolo C, Mendizabal I, Caloto R, Ercilla A, Camacho L, Arreal L,Bizkarguenaga M, Martinez-Chantar ML, Bustelo XR, Berra E, Kiss-Toth E, Velasco G, Zabala-Letona A, Carracedo A.
Genomic and Functional Regulation of TRIB1Contributes to Prostate Cancer Pathogenesis.
Cancers (Basel). 2020 Sep 11;12(9):2593. doi: 10.3390/cancers12092593. PMID: 32932846; PMCID: PMC7565426. - Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M.
Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling.
Circulation. 2020 Aug 18;142(7):688-704. doi: 10.1161/CIRCULATIONAHA.119.042354. Epub 2020 May 29. PMID: 32466671. - Bruzzone C, Loizaga-Iriarte A, Sánchez-Mosquera P, Gil-Redondo R, Astobiza I, Diercks T, Cortazar AR, Ugalde-Olano A, Schäfer H, Blanco FJ, Unda M, Cannet C, Spraul M, Mato JM, Embade N, Carracedo A, Millet O.
1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in
Prostate Cancer. J Proteome Res. 2020 Jun 5;19(6):2419-2428. doi:10.1021/acs.jproteome.0c00091. Epub 2020 May 18. PMID: 32380831. - Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.
J Exp Med. 2020 Jun 1;217(6):e20191787. doi: 10.1084/jem.20191787. PMID: 32219437; PMCID: PMC7971141. - Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigué A, Camacho L, Martín-Martín N, Cicogna P, Viera-Bardón C, Fernández-Ruiz S, Rodriguez- Hernandez I, Hermanova I, Astobiza I, Cortazar AR, Corres-Mendizabal J, Gomez- Muñoz A, Sanz-Moreno V, Torrano V, Carracedo A.
PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control.
Cancer Res. 2019 Dec 15;79(24):6153-6165. doi: 10.1158/0008-5472.CAN-19-1231. Epub 2019 Oct 8. PMID: 31594836. - Arreal L, Piva M, Fernández S, Revandkar A, Schaub-Clerigué A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zúñiga-García P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A.
Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Cell Death Differ. 2020 Apr;27(4):1186-1199. doi:10.1038/s41418-019-0407-5. Epub 2019 Oct 1. PMID: 31570853; PMCID: PMC7104349. - Valcarcel-Jimenez L, Macchia A, Martín-Martín N, Cortazar AR, Schaub-Clerigué A, Pujana-Vaquerizo M, Fernández-Ruiz S, Lacasa-Viscasillas I, Santos-Martin A, Loizaga-Iriarte A, Unda-Urzaiz M, Hermanova I, Astobiza I, Graupera M, Starkova J, Sutherland J, Barrio R, Aransay AM, Carracedo A, Torrano V.
Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer.
Cell Death Dis. 2018 Oct 11;9(10):1041. doi: 10.1038/s41419-018-1096-6. PMID: 30310055; PMCID: PMC6181952. - Cortazar AR, Torrano V, Martín-Martín N, Caro-Maldonado A, Camacho L, Hermanova I, Guruceaga E, Lorenzo-Martín LF, Caloto R, Gomis RR, Apaolaza I, Quesada V, Trka J, Gomez-Muñoz A, Vincent S, Bustelo XR, Planes FJ, Aransay AM, Carracedo A.
CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets.
Cancer Res. 2018 Nov 1;78(21):6320-6328. doi: 10.1158/0008-5472.CAN-18-1669. Epub 2018 Sep 19. PMID: 30232219. - Goicoechea I, Rezola R, Arestin M, M Caffarel M, Cortazar AR, Manterola L, Fernandez-Mercado M, Armesto M, Sole C, Larrea E, M Araujo A, Ancizar N, Plazaola A, Urruticoechea A, Carracedo A, Ruiz I, Alvarez Lopez I, H Lawrie C. (2018)
Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases.
Version 2. F1000Res. 2017 Aug 30 [revised 2018 Jan 1];6:1606. doi: 10.12688/f1000research.12393.2. - Pazos Obregón F, Soto P, Lavín JL, Cortazar AR, Barrio R, Aransay AM, Cantera R. (2018)
Cluster Locator, online analysis and visualization of gene clustering.
Bioinformatics, Volume 34, Issue 19, 1 October 2018, Pages 3377 - 3379. doi: 10.1093/bioinformatics/bty336. - Caro-Maldonado A, Camacho L, Zabala-Letona A, Torrano V, Fernández-Ruiz S, Zamacola-Bascaran K, Arreal L, Valcárcel-Jiménez L, Martín-Martín N, Flores JM, Cortazar AR, Zúñiga-García P, Arruabarrena-Aristorena A, Guillaumond F, Cabrera D, Falcón-Perez JM, Aransay AM, Gomez-Muñoz A, Olivan M, Morote J, Carracedo A. (2017)
Low-dose statin treatment increases prostate cancer aggressiveness.
Oncotarget. 2017 Oct 31;9(2):1494-1504. doi: 10.18632/oncotarget.22217. - Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. (2017)
Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470 - Martín-Martín N, Zabala-Letona A, Fernández-Ruiz S, Arreal L, Camacho L, Castillo-Martin M, Cortazar AR, Torrano V, Astobiza I, Zúñiga-García P, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcárcel-Jiménez L, Arruabarrena-Aristorena A, Piva M, Sánchez-Mosquera P, Aransay AM, Gomez-Muñoz A, Barrio R, Sutherland JD, Carracedo A.(2017)
PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
Cancer Res. 2018 Jan 15;78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908. - Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A. (2017)
Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.
Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3558. - Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. (2017)
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964 - Lavín JL, Sánchez-Morán M, Bárcena L, Cortazar AR, Macías-Cámara N, González M, Aransay AM. (2017)
A fistful of tips for a fruitful high throughput sequencing experiment.
BioEssays Volume 39(5): 1700037. - Ana R. Cortazar, José A. Oguiza, Ana M. Aransay*, José L. Lavín* (*, both corresponding authors) (2017)
VerSeDa: vertebrate secretome database
Database (Oxford) (1): baw171 - Natalia Martín-Martín, Marco Piva, Jelena Urosevic, Paula Aldaz, James D. Sutherland, Sonia Fernández-Ruiz, Leire Arreal, Verónica Torrano, Ana R. Cortazar, Evarist Planet, Marc Guiu, Nina Radosevic-Robin, Stephane Garcia, Iratxe Macías, Fernando Salvador, Giacomo Domenici, Oscar M. Rueda, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Patricia Zuñiga-García, Alfredo Caro-Maldonado, Lorea Valcárcel-Jiménez, Pilar Sánchez-Mosquera, Marta Varela-Rey, Maria Luz Martínez-Chantar, Juan Anguita, Yasir Ibrahim, Maurizio Scaltriti, Charles H. Lawrie, Ana M. Aransay, Juan L. Iovanna, Jose Baselga, Carlos Caldas, Rosa Barrio, Violeta Serra, Maria dM Vivanco, Ander Matheu, Roger R. Gomis, Arkaitz Carracedo (2016)
Stratification and therapeutic potential of PML in metastatic breast cancer
Nat Com 7: article 12595 - Verónica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zuñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena1, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, JasonW. Locasale, Roger R. Gomis and Arkaitz Carracedo (2016)
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
Nature Cell Biol 18(6):645-56 (DOI: 10.1038/ncb3357) - Felix Royo, Patricia Zuñíga-Garcia, Verónica Torrano, Ana Loizaga, Pilar Sanchez-Mosquera, Aitziber Ugalde-Olano, Esperanza González, Ana R. Cortazar, Laura Palomo, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Maria Berdasco, James D. Sutherland, Rosa Barrio, Amaia Zabala-Letona, Natalia Martín-Martín, Amaia Arruabarrena-Aristorena, Lorea Valcarcel-Jimenez, Alfredo Caro-Maldonado, Jorge Gonzalez-Tampan, Guido Cachi-Fuentes, Manel Esteller, Ana M. Aransay, Miguel Unda, Juan M. Falcón-Pérez, Arkaitz Carracedo (2016)
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Oncotarget 7(6):6835-6846 (DOI: 10.18632/oncotarget.6899) - Ana R. Cortazar, José A. Oguiza, Ana M. Aransay*, José L. Lavín* (*, both corresponding authors). (2015)
PECAS: Prokaryotic and Eukaryotic Classical Analysis of Secretome
Amino Acids. 2015 Dec;47(12):2659-63. doi: 10.1007/s00726-015-2058-2 - Ugalde-Olano A, Egia A, Fernández-Ruiz S, Loizaga-Iriarte A, Zuñiga-García P, Garcia S, Royo F, Lacasa-Viscasillas I, Castro E, Cortazar AR, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Torrano-Moya V, Valcárcel-Jiménez L, Sánchez-Mosquera P, Caro-Maldonado A, González-Tampan J, Cachi-Fuentes G, Bilbao E, Montero R, Fernández S, Arrieta E, Zorroza K, Castillo-Martín M, Serra V, Salazar E, Macías-Cámara N, Tabernero J, Baselga J, Cordón-Cardo C, Aransay AM, Villar AD, Iovanna JL, Falcón-Pérez JM, Unda M, Bilbao R, Carracedo A. (2015)
Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN.
Methods 77-78:25-30 -
Cortazar AR, Aransay AM, Alfaro M, Oguiza JA, Lavín JL (2014)
SECRETOOL: integrated secretome analysis tool for fungi.
Amino Acids.46(2):471-3.